BYETTA PI PDF

Learn about BYETTA, the BYETTA Pen. Important Safety Information for BYETTA (exenatide) injection. Contraindications. BYETTA is contraindicated in. Exenatide (Byetta) is the first in a new class of incretin peptide mimetics .. Available at ; accessed October 15, 3. Meneilly. Exenatide (marketed as Byetta, Bydureon) is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) medication, belonging to the group of incretin.

Author: Tojabei Moogubar
Country: Monaco
Language: English (Spanish)
Genre: Finance
Published (Last): 23 September 2018
Pages: 347
PDF File Size: 10.77 Mb
ePub File Size: 14.81 Mb
ISBN: 196-9-11934-175-1
Downloads: 92490
Price: Free* [*Free Regsitration Required]
Uploader: Tojarg

Postmarketing reports of serious hypersensitivity reactions eg anaphylaxis and angioedema. BYETTA slows gastric emptying and can reduce the extent and rate of absorption of orally administered drugs.

Byetta is contraindicated in patients with prior severe hypersensitivity reactions to exenatide or to any of the product components. Continue holding in the injection button while slowly counting to 5 bjetta get a full dose. Inactive Ingredients Ingredient Name Strength metacresol 2.

Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus

bywtta Similar exposure is achieved with SC administration of Byetta in the abdomen, thigh, or upper arm. Acetaminophen AUC, C max and T max were pl significantly changed when acetaminophen was given 1 hour before Byetta injection. These medical conditions can make you more likely to get pancreatitis in general. Tell your healthcare provider if you have severe problems with your stomach, such as delayed emptying of your stomach gastroparesis or problems with digesting food.

GLP-1 is a naturally occurring hormone that is released from the gastrointestinal tract and enhances the glucose-dependent insulin response 3. Baseline body weight across treatment arms was approximately kg. The pain may happen with or without vomiting. Byetta Rating 82 User Reviews 7. If and part of are in the dose window and the dose knob cannot be pushed in: Patients should be advised to inform their physicians if they are pregnant or intend to become pregnant.

  ITALO CALVINO I NOSTRI ANTENATI PDF

At 30 weeks, both exenatide treatment arms showed a mean weight change of —1. It is not known whether exenatide is excreted in human milk.

Patients in the long-term uncontrolled open-label extension studies at 52 weeks reported no new types of adverse reactions than those observed in the week controlled trials. A small air bubble in the cartridge is normal. If pancreatitis is suspected, Byetta should promptly be discontinued and appropriate management should be initiated.

Patients treated with Byetta should be informed that the concurrent use of Byetta with prandial insulin has not been studied and cannot be recommended. Do not use Byetta for a condition for which it was not prescribed. It was approved by the Food and Drug Administration FDA in April for adjunctive glycemic control in patients with type 2 diabetes mellitus who are taking metformin, a sulfonylurea, or a combination of metformin and a sulfonylurea 2.

Exenatide was approved by the FDA on April 28, for people whose diabetes was not well-controlled on other oral medication. Accessed August 28, Biochimica et Biophysica Acta. It is not known whether Byetta, or other anti-diabetes medications, increase your pk of a heart attack or stroke. All other trademarks are the trademarks of their respective owners.

Type 2 Diabetes Medication | BYETTA® (exenatide) injection

Exenatide marketed as ByettaBydureon is a glucagon-like peptide-1 receptor agonist GLP-1 receptor agonist medication, belonging to the group of incretin mimeticsapproved in April for the treatment of diabetes mellitus type 2.

The two patients who reported an injection-site reaction had high titers of antibodies to exenatide. The effect of Byetta on OC pharmacokinetics is confounded by the possible food effect on OC in this study.

Clinical trials have shown a benefit to adding exenatide to metformin and sulfonylureas.

  EMU 0404 MANUAL PDF

Patients should be informed that it is also possible that the use of Byetta with other glucose-independent insulin secretagogues e. All studies were conducted over a week period and were placebo controlled.

If you hear a click sound from your Byetta Pen, ignore it. Three byetfa, double-blind, placebo-controlled trials were conducted to evaluate the safety and efficacy of Byetta in patients with type 2 diabetes whose glycemic control was inadequate with metformin alone, a sulfonylurea alone, or metformin in combination with a sulfonylurea.

Add BYETTA to insulin glargine as a complementary action to help improve glycemic control

Byetta improves glycemic control by reducing fasting and postprandial glucose concentrations in patients with type 2 diabetes through the actions described below. Specifically, fetuses from pregnant rabbits given SC doses of 0.

AstraZeneca provides this link as a service to website visitors.

If you cannot turn the dose knob, see Commonly Asked Questions, number 7, in Section 4 of user manual. The main side effects of exenatide use are gastrointestinal in nature, including acid or sour stomach, belching, diarrhea, heartburn, indigestion, nausea, and vomiting; exenatide is therefore not meant for people with severe gastrointestinal disease.

If li is suspected, BYETTA should be discontinued promptly and should not be restarted if pancreatitis is confirmed.

Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus

Thyrotropin alfa TSH thyrotropin. Use of twice-daily exenatide in basal insulin—treated patients with type 2 diabetes: Concurrent use with prandial insulin has not been studied and cannot be recommended.

The liquid should be clear, colorless, and free of particles. With Metformin and a Sulfonylurea 30 Weeks.